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News Physiol Sci 5: 254-258, 1990;
1548-9213/90 $5.00
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News in Physiological Sciences, Vol 5, 254-258, Copyright © 1990 by International Union of Physiological Sciences

ARTICLES

Control of Insulin Secretion in Pancreatic Beta-Cells

OH Petersen

Recent studies on single cells employing both fluorometric and electrophysiological techniques reveal new aspects of metabolic regulation of cellular Ca2+ handling. Glucose-evoked increase in metabolism precedes Ca2+ influx through voltage-gated Ca2+ channels, and metabolism controls Ca2+ channel opening, not only via membrane potential changes but also more directly.




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