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News Physiol Sci 6: 56-60, 1991;
1548-9213/91 $5.00
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News in Physiological Sciences, Vol 6, 56-60, Copyright © 1991 by International Union of Physiological Sciences

ARTICLES

Variant PDGF Ligands and Receptors---Structure-function Relationship

WJ LaRochelle, N Giese, KC Robbins and SA Aaronson

Platelet-derived growth factor (PDGF) is a connective tissue cell mitogen comprised of two related chains encoded by distinct genes. Properties that distinguish these ligands include greater transforming potency of the B and more efficient secretion of the A chain. By generating immunochemical probes, as well as PDGF A and B chimeras, these properties were mapped to distinct domains. Increased transforming efficiency segregated with the ability to activate both Alpha- and Beta-PDGF receptors.


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 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Ikeda, C. Morita, M. Mizuno, T. Sada, H. Koike, and K. Kurokawa
PDGF-BB decreases systolic blood pressure through an increase in macrovascular compliance in rats
Am J Physiol Heart Circ Physiol, October 1, 1997; 273(4): H1719 - H1726.
[Abstract] [Full Text] [PDF]


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