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News Physiol Sci 6: 78-82, 1991;
1548-9213/91 $5.00
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News in Physiological Sciences, Vol 6, 78-82, Copyright © 1991 by International Union of Physiological Sciences

ARTICLES

Is Carbonic anhydrase Required for Contraction of Skeletal Muscle?

C Geers, P Wetzel and G Gros

An important step in excitation-contraction doupling is release and reuptake of Ca2+ at the sarcoplasmic reticulum membrane, which requires simultaneous transfer of counterions, probably H+. Evidence is provided that a carbonic anhydrase associated with the sarcoplasmic reticulum membrane rapidly generates the H+ necessary for this exchange.


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Localization of Carbonic Anhydrase IV in Rat and Human Heart Muscle
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