News in Physiological Sciences, Vol 6, 210-214, Copyright © 1991 by International Union of Physiological Sciences

ARTICLES

Paracrine Modulation of Baroreceptor Activity by Vascular Endothelium

MW Chapleau, G Hajduczok and FM Abboud

Arterial baroreceptors are stimulated by vascular stretch and serve to buffer fluctuations in arterial blood pressure. Factors released from endothelial cells act in a paracrine manner to modulate sensitivity of baroreceptors. Impaired endothelial cell function contributes to resetting and decreased sensitivity of baroreceptors in pathological states such as hypertension.

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