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News Physiol Sci 7: 10-15, 1992;
1548-9213/92 $5.00
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News in Physiological Sciences, Vol 7, 10-15, Copyright © 1992 by International Union of Physiological Sciences

ARTICLES

Protein Kinase C: A Second E-C Coupling Pathway in Vascular Smooth Muscle?

RA Khalil and KG Morgan

Smooth muscle excitation-concentration (E-C) coupling cannot be easily explained by myosin phosphorylation-dephosphorylation alone. Protein kinase C (PKC) may function as a second signaling pathway. Experimental tools that modify PKC activity differ markedly in specificity and utility. Spatial distribution and possible physiological substrates of PKC are discussed.




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