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News Physiol Sci 7: 34-37, 1992;
1548-9213/92 $5.00
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News in Physiological Sciences, Vol 7, 34-37, Copyright © 1992 by International Union of Physiological Sciences

ARTICLES

Modulation of Tumor Necrosis Factor by Reactive Oxygen Metabolites

L Baud, B Fouqueray, C Philippe and H Affres

Tumor necrosis factor is generated in inflammatory lesions of the glomerulus. Its release and binding are regulated by simultaneously generated reactive oxygen metabolites. The main consequence is a limitation of autocrine and paracrine action of tumor necrosis factor without any reduction of its systemic activity.




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