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News in Physiological Sciences, Vol 7, 52-56, Copyright © 1992 by International Union of Physiological Sciences
ARTICLES |
L Belardinelli and JC Shryock
Adenosine formation is augmented when the O2 supply is inadequate. Cardiac actions of adenosine can increase O2 supply (vasodilation) and decrease O2 consumption. We suggest that adenosine serves as a negative-feedback signal to correct an imbalance between O2 supply and consumption, thus acting as a cardioprotective metabolite.
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J.-W. Gu, A. L. Brady, V. Anand, M. C. Moore, W. C. Kelly, and T. H. Adair Adenosine upregulates VEGF expression in cultured myocardial vascular smooth muscle cells Am J Physiol Heart Circ Physiol, August 1, 1999; 277(2): H595 - H602. [Abstract] [Full Text] [PDF]
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 A. E. Martynyuk, T. E. Morey, L. Belardinelli, and D. M. Dennis Hyperkalemia Enhances the Effect of Adenosine on IK,ADO in Rabbit Isolated AV Nodal Myocytes and on AV Nodal Conduction in Guinea Pig Isolated Heart Circulation, January 19, 1999; 99(2): 312 - 318. [Abstract] [Full Text] [PDF]
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J. C. Shryock, S. Snowdy, P. G. Baraldi, B. Cacciari, G. Spalluto, A. Monopoli, E. Ongini, S. P. Baker, and L. Belardinelli A2A-Adenosine Receptor Reserve for Coronary Vasodilation Circulation, August 18, 1998; 98(7): 711 - 718. [Abstract] [Full Text] [PDF]
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D. M. Dennis, M.J. P. Raatikainen, J. R. Martens, and L. Belardinelli Modulation of Atrioventricular Nodal Function by Metabolic and Allosteric Regulators of Endogenous Adenosine in Guinea Pig Heart Circulation, November 15, 1996; 94(10): 2551 - 2559. [Abstract] [Full Text]
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A. Zaza, M. Rocchetti, and D. DiFrancesco Modulation of the Hyperpolarization-Activated Current (If) by Adenosine in Rabbit Sinoatrial Myocytes Circulation, August 15, 1996; 94(4): 734 - 741. [Abstract] [Full Text]
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D. Wang, J. C. Shryock, and L. Belardinelli Cellular Basis for the Negative Dromotropic Effect of Adenosine on Rabbit Single Atrioventricular Nodal Cells Circ. Res., April 1, 1996; 78(4): 697 - 706. [Abstract] [Full Text]
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