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News Physiol Sci 7: 64-69, 1992;
1548-9213/92 $5.00
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News in Physiological Sciences, Vol 7, 64-69, Copyright © 1992 by International Union of Physiological Sciences

ARTICLES

Regulation of Prostacyclin Synthesis in Endothelial Cells

TD Carter and JD Pearson

Endothelial cells synthesize prostacyclin in response to a wide variety of vasoactive stimuli. The transduction pathway is dependent on elevation of intracellular Ca2+ and specifically desensitizes cells to the stimulus used, thus providing tight temporal regulation of the release of this potent vasodilator and inhibitor of platelet aggregation.




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