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News Physiol Sci 7: 69-72, 1992;
1548-9213/92 $5.00
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News in Physiological Sciences, Vol 7, 69-72, Copyright © 1992 by International Union of Physiological Sciences

ARTICLES

Interactions in the Insulin-Like Growth Factor Signaling System

CT, Roberts Jr. and D LeRoith

The insulin-like growth factors, IGF-I and IGF-II, are mitogenic peptides structurally related to insulin, which have widespread effects on growth and differentiation during development. These effects are mediated via activation of specific cell-surface receptors, and this activation is modulated by several species of IGF-binding proteins.




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