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News Physiol Sci 7: 72-75, 1992;
1548-9213/92 $5.00
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News in Physiological Sciences, Vol 7, 72-75, Copyright © 1992 by International Union of Physiological Sciences

ARTICLES

Multiple Signaling Pathways for Platelet-Activating Factor Receptor

SD Shukla

Platelet-activating factor (PAF) receptor is coupled to multiple signaling pathways, including phospholipid turnover via phospholipases C, D, A2;Ca2+ mobilization;and activation of protein kinase C and tyrosine kinase. The cloned receptor shows homology to G protein-coupled receptors. These developments highlight receptor functions of this novel phospholipid agonist.




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