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News Physiol Sci 7: 120-123, 1992;
1548-9213/92 $5.00
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News in Physiological Sciences, Vol 7, 120-123, Copyright © 1992 by International Union of Physiological Sciences

ARTICLES

Endothelium-Derived Relaxing Factor and Endothelin in Hypertension

TF Luscher and Y Dohi

In resistance arteries, endothelium-derived nitric oxide inhibits vasoconstrictors;this and endothelium-dependent relaxations to acetylcholine are blunted in hypertension. The sensitivity of hypertensive resistance arteries with endothelium to intraluminal endothelin-1 is normal but is reduced without endothelium. Thus hypertension impairs endothelial regulation of the resistance circulation.




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