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News Physiol Sci 7: 166-172, 1992;
1548-9213/92 $5.00
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News in Physiological Sciences, Vol 7, 166-172, Copyright © 1992 by International Union of Physiological Sciences

ARTICLES

Platelet-Activating Factor - A Potent Endogenous Mediator Responsible for Coronary Vasospasm

AI Soloviev and P Braquet

Biological properties and experimental evidence suggest an important role for platelet-activating factor (PAF) as an endogenous mediator responsible for coronary vasospasm. PAF can produce both phasic (transient) and tonic (sustained) contractions in coronary arteries in different physiopathological conditions including hypoxia.




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