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News Physiol Sci 7: 181-183, 1992;
1548-9213/92 $5.00
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News in Physiological Sciences, Vol 7, 181-183, Copyright © 1992 by International Union of Physiological Sciences

ARTICLES

Nitric Oxide and Vasoactive Intestinal Peptide: Cotransmitters of Smooth Muscle Relaxation

SI Said

The L-arginine-nitric oxide pathway and vasoactive intestinal peptide, both widely distributed in tissues and organs, have different localizations, different activation and release mechanisms, and different signal-transduction systems. Their combined action, however, enhances the effectiveness of their vascular and nonvascular smooth muscle relaxation.


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