Physiology Journal of Applied Physiology
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News Physiol Sci 7: 212-215, 1992;
1548-9213/92 $5.00
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News in Physiological Sciences, Vol 7, 212-215, Copyright © 1992 by International Union of Physiological Sciences

ARTICLES

Multiple Site Effects of Extracellular ATP in Cardiac Tissues

G Vassort, F Scamps, M Puceat and O Clement

Before its degradation to adenosine, extracellular ATP released by nerves, or by cardiac cells during ischemia, induces positive inotropy related to stimulation of calcium conductance by P2-purinoceptors. Transiently ATP may also depolarize the cells and trigger arrhythmias by activating a new P3-purinoceptor that requires Mg ions.




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