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News Physiol Sci 7: 254-259, 1992;
1548-9213/92 $5.00
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News in Physiological Sciences, Vol 7, 254-259, Copyright © 1992 by International Union of Physiological Sciences

ARTICLES

Cellular Mechanisms for Ventricular Fibrillation

GE Billmann

Alterations in cardiac autonomic control cause changes in cytosolic second messenger concentrations. This may represent the cellular mechanism for malignant arrhythmias. In particular, cytosolic calcium elevations can alter cardiac impulse generation (oscillatory afterdepolarization) and impulse conduction (nonuniform repolarization), which alone or in combination could trigger ventricular fibrillation.




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