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News Physiol Sci 7: 264-270, 1992;
1548-9213/92 $5.00
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News in Physiological Sciences, Vol 7, 264-270, Copyright © 1992 by International Union of Physiological Sciences

ARTICLES

Binding of Fatty Acids to Albumin: A Case Study of Lipid-Protein Interactions

JA Hamilton

13C-nuclear magnetic resonance spectroscopy provides structural and dynamic details of lipid-protein interactions in complexes of fatty acids and serum albumin. With native fatty acids as nonperturbing probes, this determines microscopic properties of fatty acids in individual binding sites of albumin, rather than average properties reflecting multiple binding sites.


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