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News Physiol Sci 7: 270-274, 1992;
1548-9213/92 $5.00
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News in Physiological Sciences, Vol 7, 270-274, Copyright © 1992 by International Union of Physiological Sciences

ARTICLES

Importance of Mg2+ in Excitation-Contraction Coupling in Skeletal Muscle

GD Lamb and DG Stephenson

In skeletal muscle, how excitation rapidly triggers Ca2+ release from internal stores is not known exactly. In addition to its many other roles, intracellular Mg2+ binds to the Ca2+ release channels and strongly inhibits their opening. Excitation may actually remove this inhibition by inducing dissociation of Mg2+.




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