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News Physiol Sci 7: 274-278, 1992;
1548-9213/92 $5.00
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News in Physiological Sciences, Vol 7, 274-278, Copyright © 1992 by International Union of Physiological Sciences

ARTICLES

Platelet ADP Receptors Stimulating Shape Change and Inhibiting Adenylate Cyclase

RW Colman

Aggregin, a platelet surface membrane protein required for ADP-induced shape change, aggregation, and fibrinogen binding, is distinct from the receptor coupled to adenylate cyclase. Platelet aggregation by epinephrine, thromboxane A2, and collagen requires ADP binding to aggregin. Thrombin and plasmin are independent of ADP and activate platelet calpain, which cleaves aggregin.




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