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News Physiol Sci 8: 3-7, 1993;
1548-9213/93 $5.00
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News in Physiological Sciences, Vol 8, 3-7, Copyright © 1993 by International Union of Physiological Sciences

ARTICLES

Phosphotyrosine Protein Phosphatases: Master Key Enzymes in Signal Transduction

C Van Hoof, J Goris and W Merlevede

Tyrosine phosphorylation plays a crucial role in the regulation of cellular events. Phosphotyrosine phosphatases are pivotal enzymes in quenching signals and could thus be considered as high-specificity safety devices, screening intra- and extracellular signal transduction to engineer a coordinated control of cell function, proliferation, and differentiation.




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