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News Physiol Sci 8: 38-41, 1993;
1548-9213/93 $5.00
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News in Physiological Sciences, Vol 8, 38-41, Copyright © 1993 by International Union of Physiological Sciences

ARTICLES

Sodium Channelopathies: Dramatic Diseases Caused

EP Hoffman and SJ Spier

Very recently, the first vertebrate genetic diseases caused by abnormal voltage-sensitive channels have been found in humans and horses: single amino acid changes within the 1,700-amino acid adult skeletal muscle sodium channel result in potassium-induced muscle paralysis or cold-induced muscle contraction.




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