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News Physiol Sci 8: 61-63, 1993;
1548-9213/93 $5.00
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News in Physiological Sciences, Vol 8, 61-63, Copyright © 1993 by International Union of Physiological Sciences

ARTICLES

Dual Regulation of Phospolipase C Activity by G Proteins

H Deckmyn, C Van Geet and J Vermylen

Some subtypes of phosphatidylinositide-specific phospholipase C (PLC) are activated via pertussis toxin-sensitive or -insensitive G proteins. However, a G protein-dependent PLC inhibitory pathway also may exist. The resultant picture is of dual regulation of PLC, showing a close parallelism with the dual regulation of adenylate cyclase.




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