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News Physiol Sci 8: 74-79, 1993;
1548-9213/93 $5.00
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News in Physiological Sciences, Vol 8, 74-79, Copyright © 1993 by International Union of Physiological Sciences

ARTICLES

A Role for Tubuloglomerular Feedback in Chronic Partial Ureteral Obstruction

P Morsing

Animals with partial ureteral obstruction have an inability to increase urinary output and glomerular filtration rate in response to an extracellular volume expansion. The mechanism may be a paradoxical resetting of tubuloglomerular feedback in the obstructed kidney, which impacts the roles of arachidonic acid metabolites and kinins in renal function.




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