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News Physiol Sci 8: 145-148, 1993;
1548-9213/93 $5.00
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News in Physiological Sciences, Vol 8, 145-148, Copyright © 1993 by International Union of Physiological Sciences

ARTICLES

Endothelial Dysfunction in Shock States

AGB Kovach and AM Lefer

Circulatory shock results in dysfunction of the endothelium in various vascular beds. This dysfunction is characterized by marked impairment in the vasculature's ability to relax to endothelium-dependent vasodilators. This loss of endothelium-derived relaxing factor, or nitric oxide, leads to profound tissue injury.




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