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News Physiol Sci 8: 175-178, 1993;
1548-9213/93 $5.00
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News in Physiological Sciences, Vol 8, 175-178, Copyright © 1993 by International Union of Physiological Sciences

ARTICLES

A Protein With a Single Transmembrane Domain Forms an Ion Channel

T Takumi

Isk is a small membrane protein with a single membrane-spanning domain and shows a slow voltage-dependent K+ channel activity. Mutational analyses showed that Isk forms an integral part of the K+ channel itself. Two other proteins have similar properties, suggesting a new group of voltage-dependent channels.




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