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News Physiol Sci 8: 207-212, 1993;
1548-9213/93 $5.00
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News in Physiological Sciences, Vol 8, 207-212, Copyright © 1993 by International Union of Physiological Sciences

ARTICLES

Cholinergic Excitation of Smooth Muscle

SM Sims and LJ Janssen

Acetylcholine activates muscarinic receptors on smooth muscle to cause depolarization and contraction. Several mechanisms can contribute to depolarization, including activation of inward cation and Cl- currents, suppression of outward K+ currents, and augmentation of voltage-dependent Ca2+ current. Acetylcholine also releases Ca2+ from internal stores, directly contributing to contraction.




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