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News Physiol Sci 8: 261-266, 1993;
1548-9213/93 $5.00
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News in Physiological Sciences, Vol 8, 261-266, Copyright © 1993 by International Union of Physiological Sciences


ARTICLES

Regulation of Atrial Natriuretic Peptide Secretion

H Ruskoaho and O Vuolteenaho

The major determinant of atrial natriuretic peptide (ANP) secretion is myocyte stretch. Other stimuli, affecting the activity of protein kinase C and the intracellular concentrations of Ca2+ and adenosine 3', 5'-cyclic monophosphate, can act as secretagogues. Evidence that ANP released from ventricular myocytes contributes to plasma ANP levels is also reviewed.





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