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News Physiol Sci 9: 49-53, 1994;
1548-9213/94 $5.00
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News in Physiological Sciences, Vol 9, 49-53, Copyright © 1994 by International Union of Physiological Sciences

ARTICLES

ATP-Induced K+ Current Oscillation in Megakaryocytes: A Unique Purinoceptor

N Akaike and H Uneyama

Megakaryocytes respond to externally applied ATP and ADP, showing a periodic K+ current that reflects oscillation in cytoplasmic calcium concentration ([Ca2+] i). The agonist selectivity of the purinoceptor on the megakaryocyte is unique. In addition, the intracellular mechanism of [Ca2+]i oscillation was investigated, and a model is proposed.


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B. Somasundaram and M. P. Mahaut-Smith
A Novel Monovalent Cation Channel Activated by Inositol Trisphosphate in the Plasma Membrane of Rat Megakaryocytes
J. Biol. Chem., July 14, 1995; 270(28): 16638 - 16644.
[Abstract] [Full Text] [PDF]


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