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News Physiol Sci 9: 53-59, 1994;
1548-9213/94 $5.00
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News in Physiological Sciences, Vol 9, 53-59, Copyright © 1994 by International Union of Physiological Sciences


ARTICLES

Molecular Mechanisms of Mechanoreceptor Adaptation

OP Hamill and DW, McBride Jr.

Mechanoreceptor adaptation to maintained stimulation serves to maximize dynamic sensitivity over a broad stimulus domain. Mechanosensitive channel currents in hair cells and oocytes show similar voltage-dependent adaptation. However, in the hair cell, adaptation appears dependent on Ca2+ influx, whereas in the oocyte, it is intrinsically voltage sensitive.





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