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News Physiol Sci 9: 71-76, 1994;
1548-9213/94 $5.00
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News in Physiological Sciences, Vol 9, 71-76, Copyright © 1994 by International Union of Physiological Sciences

ARTICLES

Signal Transduction by Intramitochondrial Ca2+ in Mammalian Energy Metabolism

JG McCormack and RM Denton

Hormones and other extracellular agents often stimulate energy-requiring processes such as muscle contraction and secretion through increases in cytosolic calcium. To preserve energy homeostasis, ATP formation must also be stimulated. One important mechanism involves increases in mitochondrial calcium and activation of key steps in the process of oxidative phosphorylation.




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