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News Physiol Sci 9: 77-79, 1994;
1548-9213/94 $5.00
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News in Physiological Sciences, Vol 9, 77-79, Copyright © 1994 by International Union of Physiological Sciences

ARTICLES

Particular Sensitivity of the Mammalian Heart Sinus Node Cells

J Petit-Jacques, J Bescond, P Bois and J Lenfant

High resting adenylate cyclase activity, implying a high basal adenosine 3', 5'-cyclic monophosphate level, seems to be a distinctive property of sinoatrial node cells of mammalian heart. This may explain why acetylcholine depresses two ionic mechanisms involved in spontaneous activity of nodal myocytes, via inhibition of adenylate cyclase activity, without previous b-adrenergic stimulation.




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