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News Physiol Sci 9: 134-137, 1994;
1548-9213/94 $5.00
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News in Physiological Sciences, Vol 9, 134-137, Copyright © 1994 by International Union of Physiological Sciences

ARTICLES

A Signaling Pathway Involving Cyclic ADP-Ribose, cGMP, and Nitric Oxide

HC Lee

Cyclic nucleotides are second messengers effecting changes mainly through protein phosphorylation. Cyclic ADP-ribose (cADPR), a newly discovered member, instead exerts its function through calcium mobilization. Increasing evidence suggests that cADPR may mediate the effects of nitric oxide on calcium, with guanosine 3', 5'-cyclic monophosphate serving as an intermediate.




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