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News Physiol Sci 9: 178-183, 1994;
1548-9213/94 $5.00
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News in Physiological Sciences, Vol 9, 178-183, Copyright © 1994 by International Union of Physiological Sciences

ARTICLES

Resistance to Infection With Intracellular Parasites. Identification of a Candidate Gene

SM Vidal and P Gros

In the mouse, natural resistance to infection with unrelated intracellular parasites is controlled by the Bcg locus. With an positional cloning approach, a candidate gene for Bcg has been isolated. This gene encodes for a novel macrophage-specific transport protein, Nramp, which is altered in innately susceptible animals.


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