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News Physiol Sci 9: 208-214, 1994;
1548-9213/94 $5.00
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News in Physiological Sciences, Vol 9, 208-214, Copyright © 1994 by International Union of Physiological Sciences

ARTICLES

Oncogene-Transformed Renal Cell Lines: Physiological and Oncogenetic Studies

PM Ronco, D Prie, R Piedagnel and B Lelongt

Use of inducible oncogenes has recently boosted interest in immortalized cell lines derived by transfection of primary cultures or from transgenic mice. When the oncogene is functional, cells exhibit a transformed phenotype, whereas upon oncogene inactivation, they can differentiate up to the level of the parental cells.




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