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News Physiol Sci 9: 256-260, 1994;
1548-9213/94 $5.00
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News in Physiological Sciences, Vol 9, 256-260, Copyright © 1994 by International Union of Physiological Sciences

ARTICLES

Calcium: A Trigger for Long-Term Depression and Potentiation in the Hippocampus

D Debanne and SM Thompson

Two opposing types of plasticity at excitatory synapses in the hippocampus, long-term potentiation and depression, require N-methyl-D-aspartate receptor activation and Ca2+ influx for their induction.The direction of the change in synaptic strength is determined by a balance between phosphorylation and dephosphorylation, as regulated by protein kinases and phosphatases that are activated selectively by different levels of intracellular Ca2+.


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