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News in Physiological Sciences, Vol 11, 114-119, Copyright © 1996 by International Union of Physiological Sciences
ARTICLES |
MB Reid
Skeletal muscle produces oxygen radicals, nitric oxide, and a variety of redox-active derivatives that modulate muscle function under physiological conditions. In unfatigued muscle, reactive oxygen intermediates and nitric oxide exert opposing effects on excitation-contraction coupling. During strenuous exercise, oxidants accumulate in the tissue and accelerate the fatigue process.
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