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News Physiol Sci 12: 1-9, 1997;
1548-9213/97 $5.00
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News in Physiological Sciences, Vol 12, 1-9, Copyright © 1997 by International Union of Physiological Sciences

ARTICLES

Fever: How May Circulating Pyrogens Signal the Brain?

CM Blatteis and E Sehic

Recent data suggest that fever may be initiated by products of liver macrophages that activate subdiaphragmatic vagal afferents. In the brain, these inputs may be transmitted to fever-producing sites via noradrenergic pathways;prostaglandin E2 may be the ultimate pyrogenic mediator.


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