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News Physiol Sci 13: 112-117, 1998;
1548-9213/98 $5.00
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News in Physiological Sciences, Vol. 13, No. 3, 112-117, June 1998
© 1998 Int. Union Physiol. Sci./Am. Physiol. Soc.

Maxi-KCa, a Unique Member of the Voltage-Gated K Channel Superfamily

L. Toro, M. Wallner, P. Meera and Y. Tanaka

L. Toro, M. Wallner, and P. Meera are in the Dept. of Anesthesiology at the University of California at Los Angeles School of Medicine, Los Angeles, CA 90095–1778, USA. Y. Tanaka is in the Dept. of Pharmacology, School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi-City, Chiba 274, Japan.
Large-conductance, voltage-, and Ca2+-sensitive K+ (maxi-KCa) channels regulate neuronal and smooth muscle excitability. Their pore-forming {alpha}-subunit shows similarities with voltage-gated channels and indeed can open in the practical absence of Ca2+. The NH2 terminus is unique, with a seventh transmembrane segment involved in ß-subunit modulation. The long COOH terminus is implied in Ca2+ modulation.




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