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News Physiol Sci 13: 211-217, 1998;
1548-9213/98 $5.00
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News in Physiological Sciences, Vol. 13, No. 5, 211-217, October 1998
© 1998 Int. Union Physiol. Sci./Am. Physiol. Soc.

Calcium Channels Formed by Mammalian Trp Homologues

Xi Zhu and Lutz Birnbaumer

X. Zhu is Assistant Professor of the Dept. of Pharmacology and the Neurobiotechnology Center, Ohio State Univ., Columbus, OH 43210, USA; L. Birnbaumer is Professor and Chairman of the Dept. of Molecular, Cell, and Developmental Biology, Univ. of California at Los Angeles, Los Angeles, CA 90095, USA.
Homologues of Drosophila trp genes have been isolated from mammalian species in hope that they may constitute the molecular basis of capacitative Ca2+ entry. Expression of Trps suggests that they form Ca2+ influx channels regulated by either store depletion or a more upstream event. Store-operated Trp channels can be formed by heteromultimerization.




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