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News Physiol Sci 16: 126-130, 2001;
1548-9213/01 $5.00
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News in Physiological Sciences, Vol. 16, No. 3, 126-130, June 2001
© 2001 Int. Union Physiol. Sci./Am. Physiol. Soc.

Molecular Structure of Tight Junctions and Their Role in Epithelial Transport

James Melvin Anderson

J. M. Anderson is a Professor of Medicine and Cell Biology at the Yale School of Medicine, New Haven, Connecticut 06520-8019.
Tight junctions create a paracellular barrier with physiological properties that differ among epithelia. Among these differences are electrical resistance and discrimination for solute size and charge. Emerging evidence suggests that a large family of transmembrane proteins called the claudins create these variable properties.




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