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Neuropeptide Y: Neurotransmitter or Trophic Factor in the Heart?

Lev Protas¹, Jihong Qu¹ and Richard B. Robinson^1,2

¹ Department of Pharmacology and
² Center for Molecular Therapeutics, Columbia University, New York, New York 10032
Neuropeptide Y (NPY) is released from sympathetic neurons and exerts short-term (acute) effects on prejunctional nerve terminals and postjunctional cardiac ion channels. However, NPY also exerts long-term (trophic) effects on angiogenesis, cardiac hypertrophy, autonomic signaling, and cardiac ion channels, including effects on L-type Ca²⁺ and pacemaker channels.

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				A. E.G. Lomax, K. A. Sharkey, and W. R. Giles Neuropeptide Y Modulates L-Type Ca2+ Current During Heart Development Circ. Res., November 14, 2003; 93(10): 891 - 892. [Full Text] [PDF]