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REVIEW
Program in Vascular Cell Engineering; Departments of Pediatrics, Medicine, Oncology, and Radiation Oncology; and Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
gsemenza{at}jhmi.edu
The ability to sense and respond to changes in oxygenation represents a fundamental property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the identification of protein hydroxylation as a mechanism by which changes in PO2 are transduced to effect changes in gene expression.
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