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Physiology 20: 326-339, 2005; doi:10.1152/physiol.00011.2005
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 5, 326-339, October 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Type III Secretion: More Systems Than You Think

Paul Troisfontaines and Guy R. Cornelis

Biozentrum der Universität Basel, CH-4056 Basel, Switzerland

guy.cornelis{at}unibas.ch

The type III secretion (T3S) pathway allows bacteria to inject effector proteins into the cytosol of target animal or plant cells. T3S systems evolved into seven families that were distributed among Gram-negative bacteria by horizontal gene transfer. There are probably a few hundred effectors interfering with control and signaling in eukaryotic cells and offering a wealth of new tools to cell biologists.




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