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REVIEW
1 Division of Molecular Physiology and
2 MRC Protein Phosphorylation Unit, University of Dundee, Dundee, Scotland
d.g.hardie{at}dundee.ac.uk
Contraction induces marked metabolic changes in muscle, and the AMP-activated protein kinase (AMPK) is a good candidate to explain these effects. Recent work using a muscle-specific knockout of the upstream kinase, LKB1, has confirmed that the LKB1
AMPK cascade is the signaling pathway responsible for many of these effects.
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