Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiology 21: 404-410, 2006; doi:10.1152/physiol.00031.2006
1548-9213/06 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (6)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Anastasiou, D.
Right arrow Articles by Krek, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Anastasiou, D.
Right arrow Articles by Krek, W.
Physiology, Vol. 21, No. 6, 404-410, December 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

SIRT1: Linking Adaptive Cellular Responses to Aging-Associated Changes in Organismal Physiology

Dimitrios Anastasiou and Wilhelm Krek

Institute of Cell Biology, ETH Zurich, Zurich, Switzerland wilhelm.krek{at}cell.biol.ethz.ch

Sirtuins comprise a family of enzymes implicated in the determination of organismal life span in yeast and the nematode. The mammalian sirtuin SIRT1 has been shown to deacetylate several proteins in an NAD+-dependent manner. SIRT1 substrates are involved in the regulation of apoptosis/cell survival, endocrine signaling, differentiation, chromatin remodeling, and transcription. Thus SIRT1 provides a molecular link between nutrient availability and adaptive transcriptional responses. This review presents current evidence as to how SIRT1 functions are relevant to changes in tissue physiology that occur with ageing and its implications for future pharmacological intervention to alleviate such degenerative processes.




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
K. A. Rasbach and R. G. Schnellmann
Isoflavones Promote Mitochondrial Biogenesis
J. Pharmacol. Exp. Ther., May 1, 2008; 325(2): 536 - 543.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2006 by the Int. Union Physiol. Sci./Am. Physiol. Soc.