Role of Extracellular Adenosine in Acute Lung Injury

Tobias Eckle, Michael Koeppen, Holger K. Eltzschig


Acute lung injury (ALI) is a lung disease characterized by pulmonary edema and severe hypoxia. The past decade hosted a search for endogenous mechanisms controlling lung inflammation and pulmonary edema during ALI. As such, recent evidence indicates extracellular adenosine in orchestrating the resolution of pulmonary edema and inflammation during ALI.

Adenosine represents an endogenous signaling molecule that dampens pulmonary edema and promotes resolution of lung inflammation during acute lung injury.

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