Voltage-Gated Proton Channels Find Their Dream Job Managing the Respiratory Burst in Phagocytes

Thomas E. DeCoursey

Abstract

The voltage-gated proton channel bears surprising resemblance to the voltage-sensing domain (S1–S4) of other voltage-gated ion channels but is a dimer with two conduction pathways. The proton channel seems designed for efficient proton extrusion from cells. In phagocytes, it facilitates the production of reactive oxygen species by NADPH oxidase.

Identification of the proton channel gene has enabled new approaches to understanding its physiological roles in phagocytes and other cells.

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