Energy Landscapes as a Tool to Integrate GPCR Structure, Dynamics, and Function

Xavier Deupi, Brian K. Kobilka

Abstract

G protein-coupled receptors (GPCRs) are versatile signaling molecules that mediate the majority of physiological responses to hormones and neurotransmitters. Recent high-resolution structural insights into GPCR structure and dynamics are beginning to shed light on the molecular basis of this versatility. We use energy landscapes to conceptualize the link between structure and function.

Footnotes

  • This work was supported by the Ministerio de Educación y Ciencia (Spain) through the Ramon y Cajal Program (to X. Deupi) and the National Institute of Neurological Disorders and Stroke Grant NS-028471 and the Mathers Charitable Foundation (to B. K. Kobilka).

  • No conflicts of interest, financial or otherwise, are declared by the author(s).

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