TMEM16A Protein: A New Identity for Ca2+-Dependent Cl Channels

Loretta Ferrera, Antonella Caputo, Luis J. V. Galietta


Ca+-dependent Cl channels (CaCCs) play a variety of physiological roles in different organs and tissues, including transepithelial Cl secretion, smooth muscle contraction, regulation of neuronal excitability, and transduction of sensory stimuli. The recent identification of TMEM16A protein as an important component of CaCCs should allow a better understanding of their physiological role, structure-function relationship, and regulatory mechanisms.


  • No conflicts of interest, financial or otherwise, are declared by the author(s).

View Full Text