Role of TRP Channels in the Regulation of the Endosomal Pathway

Ken Abe, Rosa Puertollano

Abstract

Some members of the transient receptor potential (TRP) channel superfamily have proved to be essential in maintaining adequate ion homeostasis, signaling, and membrane trafficking in the endosomal pathway. The unique properties of the TRP channels confer cells the ability to integrate cytosolic and intraluminal stimuli and allow maintained and regulated release of Ca2+ from endosomes and lysosomes.

Footnotes

  • This project was supported by the Intramural Research Program of the National Heart, Lung, and Blood Institute.

  • No conflicts of interest, financial or otherwise, are declared by the author(s).

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