A Cool Channel in Cold Transduction

Ramón Latorre, Sebastián Brauchi, Rodolfo Madrid, Patricio Orio


Transient receptor potential melastatin 8 (TRPM8), a calcium-permeable cation channel activated by cold, cooling compounds and voltage, is the main molecular entity responsible for detection of cold temperatures in the somatosensory system. Here, we review the biophysical properties, physiological role, and near-membrane trafficking of this exciting polymodal ion channel.


  • Authors are supported by Fondecyt Grants 1090493 and 1110430 to R. Latorre; 1110906 to S. Brauchi; 1100983 to R. Madrid; 11090308 to P. Orio; R. Madrid thanks the support of Vicerrectoría de Investigación y Desarrollo of the University of Santiago de Chile. The Centro Interdisciplinario de Neurociencia de Valparaíso is a Millenium Science Institute.

  • No conflicts of interest, financial or otherwise, are declared by the author(s).

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